O que há no próximo número da Nature Reviews: Drug Discovery

Therapeutic targets to reduce cardiovascular disease in type 2 diabetes
This Perspective considers the implications of recent regulatory guidance on the development of new drugs for diabetes and discusses the potential cardiovascular effects of selected classes of diabetes drugs.


Targeting DNA topoisomerase II in cancer chemotherapy
Recent molecular studies could help refine targeting of topoisomerase II as an effective anticancer strategy.


Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies
Adjuvant interleukin-7 (IL-7) improves antitumor responses and survival in a mouse model in which an antitumor response can be elicited through viral vaccination.


A new screening assay for allosteric inhibitors of cSrc
A direct binding assay detects small molecules that stabilize the inactive conformation of the tyrosine kinase cSrc.

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